High doses of vitamin D and a higher incidence of chronic diseases
April 27th, 2010 | By adminAnd 'well known that vitamin D deficiency is associated with osteoporosis, bone fractures, increased falls, muscle weakness, increased risk of certain cancers (particularly breast and colon and possibly prostate), autoimmune diseases, obesity, insulin resistance and type 2 diabetes, schizophrenia, depression, asthma, lung disease, influenza, kidney disease, hypertension and cardiovascular disease. Although complications of pregnancy, preeclampsia (pregnancy-induced hypertension)and gestational diabetes is associated with deficiency of vitamin D. Children are vitamin D insufficiency is associated with low birth weight (maternal vitamin D deficiency), neonatal hypocalcemia (calcium in the blood), poor postnatal growth, osteoporosis and increased incidence of autoimmune diseases and childhood asthma.
Vitamin D helps prevent osteoporosis
The recommended standard dose of 400 IU / day of vitamin D is generally helping to maintain "good health"and help reduce the risk of osteoporosis, falls and hip fractures. Over the past five years, there is an explosion of studies expand our knowledge, suggesting that higher doses of vitamin D is much more of an effect on general health and prevention of many chronic diseases, the development of bones and the prevention of 'osteoporosis. The default while I was practicing soccer physician, is recommended magnesium, and vitamin D for women of menopausal age. But Inow suggest vitamin D levels much, much greater than 400 IU / day.
Vitamin D may help prevent insulin resistance
A common problem I've seen in my medical practice associated with age and was greater insulin resistance, which often leads to metabolic syndrome or type 2 diabetes in its own right. To reduce the risk of diabetes, metabolic syndrome, insulin resistance, and I urge my patients a diet low glycemic index, exercise at least four times a week to maintain, andon a broad spectrum supplements program. Often the difference for people who are serious and significant changes.
Insulin resistance begins with the oxidation of insulin receptors. With the continued oxidation and inflammation of insulin receptors in scale type 2 diabetes develops. Finally, having discovered that vitamin D deficiency is a contributing factor to insulin resistance, giving further support to my top recommended doses of vitaminD.
Although not all studies have been consistent in fighting insulin resistance with vitamin D supplements, studies, these advantages have when the blood serum of vitamin D (25-hydroxvitamin D or 25-OH D) concentrations were at least in the range of 35 -42 ng / ml.
Vitamin D is associated with reduced risk of breast cancer and colon
As a former practicing board-certified OB / GYN, I have many patients who have a history of breast cancer, or a family werehistory of breast cancer. Colon cancer is also a problem because the appearance is second to breast cancer. A reduced risk of breast cancer and colon cancer (and perhaps prostate cancer) is linked when the blood serum of vitamin D (25-OH-D) is 40 ng / ml or more.
I have many patients with tamoxifen to treat or suppress the recurrence of breast cancer. But tamoxifen has its problems. Interestingly, the drugs used to treat breast cancer as tamoxifen,Vitamin D apoptosis in breast cancer cells and trigger self-destruction of cancer cells (like many other antioxidants, such as turmeric extract, polyphenolic compounds, for example, grape seed extract, the extract of cruciferous , resveratrol, green tea extract), but without the concerns that toxic substances. While this information is too early to be used for cancer-treatment drugs to replace a lot of promise for vitamin D and other antioxidants against cancer. As I searchedfind out what dose of vitamin D Should women take, I discovered that science association between women whose serum 25-OH-D levels at least 52 ng / ml or more and 50% reduction in the incidence of breast cancer have shown.
As I speak of "power supplements" I suggest that, among other nutrients, considering there are so many potential health benefits derived from supplements of vitamin D (and other food supplements), and almost no toxicIndeed, why should someone wait to fill?
Vitamin D and reduced risk of heart disease
The vitamin D deficiency increases the risk of both non-ischemic and ischemic heart disease. Vitamin D helps control blood pressure, its effect on parathyroid hormone levels affect the function of the heart muscle, and plays a role in reducing inflammation and calcification of blood vessels and thus help reduce atherosclerosis.
The risk of heart disease is primarily a highwhen vitamin D in their blood below 15 ng / ml. With levels of 25-OH vitamin D above 30 ng / ml cardiac benefits can be substantial. It 'clear that more studies need to conclusions about the role of vitamin D'drawing's in maintaining and / or reduction of cardiovascular disease, but again, I can only say that there is now sufficient evidence when it is as a whole, for all to consider supplementing with adequate doses of this vitamin is very important for any or all "of danger to healthbenefits.
Vitamin D and reduced risk of influenza
It 'also found that vitamin D reduces the incidence of respiratory infections. Children are the D lower 25-hydroxyvitamin in their blood are 11 times more likely to develop respiratory infections. I was asked about the safety and efficacy of the baby vitamin D. One can only look at the clinical data. Children with recurrent respiratory infections had higherDose 60 000 IU vitamin D per week (six weeks) and is not such an infection in the next six months to have!
Many people suffer and die from pneumonia or influenza. "They die from the infection of the virus itself, as much as the overreaction of the body. Influenza viruses cause uncontrolled overproduction of inflammatory cytokines. Interestingly, vitamin D by the process" down regulate "the expression of pro-inflammatory cytokines, such astumor necrosis factor-alpha.
In fact, the pro-inflammatory cytokines, the inflammatory process that occurs in chronic diseases such as inflammation of the veins of atherosclerosis, inflammation, arthritis, damage to neurons, and inflammation and damage caused by tumor cells and the process of aging itself.
Think of the possibilities of reducing inflammation by down-regulation of cytokines (tumor necrosis factor alpha, etc.) and thereby reduce the incidence andprogression of many chronic degenerative diseases such as heart disease, cancer, Alzheimer's, arthritis, diabetes, respiratory infections, liver and kidney disease and aging itself! This is what this article is not to say that vitamin D is proven …. not to, but is still vitamin D, which shows that it is involved in these processes to assist in good health and reducing disease maintain, along with other vitamins, minerals,and antioxidants.
As for vitamin D and protection of respiratory infections and influenza, as well as downregulation of inflammatory cytokines, vitamin D also regulates the expression of antimicrobial peptides in immune cells. antimicrobial peptides damage the outer membrane lipids of influenza viruses, bacteria and fungi, such as white blood cells (macrophages) immune system to connect the body.
I suggest that adults and childrenfill with much higher doses of vitamin D, as traditionally recommended to prevent respiratory infections and helping to reduce the immune system, especially in winter, when exposure to sunlight is decreased.
Vitamin D and reduced risk of complications in pregnancy
Maintaining health during pregnancy is a big problem for me, and women are still very ciritical cellular nutrition in pregnancy. Optimalsupplements should be before a woman knows she is pregnant again. This is why I urge all women of childbearing age in a wide range of quality food products. Now with the latest information on the benefits of vitamin D during Prenancy, the amount of vitamin D in prenatal vitamins is quite inadequate, … at least in my opinion.
Vitamin D plays an important role in calcium metabolism during pregnancy and development in order to preventchild and adult rickets osteomalacia. During pregnancy, the claims of calcium rapidly, especially in the third quarter. Because of this, vitamin D, calcium, the incorporation of critical mass necessary for proper bone growth and skeletal optimal maternal and fetal outcomes. Despite the widespread use of prenatal vitamins contain deemed "adequate" doses of vitamin D, there is still a lack of vitamin D epidemic among pregnant andbreastfeeding women.
And 'the more important that a pregnant woman has a better vitamin D in the blood of a pregnant woman the health of your child depends on it … not only in fetal life, but in the next two decades! child's life
Low levels of vitamin D during pregnancy and the child is related to maternal preeclampsia and pregnancy-induced hypertension, low birth weight and neonatal hypocalcemia, poor postnatal growth, osteoporosis and a higher incidence ofautoimmune diseases and asthma in children.
During pregnancy, a minimum of vitamin D in their blood (25-hydroxyvitamin D) should be 32 ng / ml or more, and most are closer to 50 ng / ml. To achieve and maintain 25-D hydroxvitamin serum 32-50 ng / ml suggest that pregnant women and breast-feeding may be necessary to supplement with a dose between 2000 and 4000 IU / day of vitamin D3 per day, which is both safe and effective. It is of course beyond the level of resultsin all prenatal vitamins.
Asthma in children linked to vitamin D deficiency
The epidemic of asthma may be declared in part of vitamin D deficiency epidemic. There is a direct correlation between low serum levels of vitamin D and increased risk of asthma exacerbations. Vitamin D plays a role in fetal lung growth and development. Epidemiological evidence that a high intake of prenatal vitamin D has a protective role against wheezing illnesschildren. Vitamin D may protect against wheezing illness through its various immune effects as described above. Moreover, vitamin D has a therapeutic role in asthma, steroid-resistant.
Above I suggested that vitamin D plays an important role in reducing the risk of respiratory infections. In children and adults in the case of asthma, high doses of vitamin D is even more important as a respiratory infection can triggerattacks.
Measuring Your Vitamin D
The question on many people's heads is: "How much vitamin D is the right dose?" The best way to a man "right" to know that a dose of 25-hydroxyvitamin D in their blood to know. This is the metabolically active form of vitamin D, and is also known as calcidiol. And 'reduced to 25-OH-D. In the past, adequate "blood" is set to prevent rickets and osteoporosis in later years. But it's many benefits and safety of vitamin Dlight (excuse pun).
Most laboratories have a normal reference range for 25-OH-D 32-100 ng / ml. After an investigation that many of the experts on treatment of vitamin D is recommended varies widely, was in line with that reported that their "optimal serum 25-OH-D level should be between 50-80 ng / ml.
How much vitamin D is optimal?
Vitamin D, the dose needed for a variety serum level of 50-80 ng / ml to achieve vary from person to person,based primarily on body mass (weight) and exposure to the sun. Although vary, 150 pounds with a person supplement of 2000 IU vitamin D per day can vary from blood 25-OH-D is between 30 and 45 ng / ml, depending on sun exposure. In my experience, it seems that the same person can have 4,000 IU / day or more than optimal blood between 50 and 80 ng / ml.
Again, this is from my experience on this scale that goes ,…. A person who weighs 225 pounds. canrequire 10 000 IU / day, 25-hydroxyvitamin D in blood serum levels between 50 and 80 ng maintain / ml. dose of a real person can only be determined by blood tests and titration (adjustment based on blood tests).
My suggestion would be to start on either vitamin D 4000-6000 IU / day, depending on weight, you can safely choose 10,000 IU / day, and then have your blood test 25-OH-D about 6-8 weeks later. For the optimal target blood for optimal healthand 50-80 ng / ml. Therefore, when you know your blood, you can create the intake of vitamin D should be adjusted.
Are high doses of vitamin D safe?
Is the term "high dose" of vitamin D3 is safe? We can ensure that high doses of vitamin D serum levels of calcium can cause kidney stones increase the risk of being. There was a study in which vitamin D deficiency in patients have not received a single oral or intramuscular injection of 300,000 IU of vitamin D andfollowed for 12 weeks. Over 12 weeks, not a person of an increase in serum calcium (or hypercalcemia).
This does not mean that chronic super-high doses of vitamin D increases calcium levels in the blood, but there are no credible reports of chronic vitamin D intoxication vitamin D3 daily supplements to 10,000 IU / day, including high blood calcium. In fact, many medical experts regular vitamin D recommended doses well above 10,000 IU / day. Hypercalcemia(An increase in serum calcium levels) was observed only with synthetic analogues of vitamin D, as calcitriol.
Since it is safe for most people to supplement with vitamin D at doses as high as 10,000 IU / day (and maybe more), without worry, my recommendation of an initial dose of 4000-6000 IU / day is very conservative .
And contraindications to high dose of vitamin D?
Primary hyperparathyroidism is the main contraindication. Even a high dose of vitamin Dsupplements may increase serum calcium in patients with sarcoidosis, tuberculosis, or lymphoma. Therefore, in these cases, patients with dose levels beyond 2000 IU a day just to do so with caution and care and guidance of a physician.
One last word: Reports and maintain a proper balance of vitamins
Vitamin D is naturally safe. It is underestimated as an important vitamin for many decades to maintain optimal healthless, and possibly to reduce the risk of many chronic diseases such as saline injection for optimal blood. It, however, like all other vitamins, minerals, antioxidants, essential fatty acids or other nutrients, vitamin D must be balanced! All the necessary nutrients for a healthy diet to complement, and used in conjunction with exercise and a healthy lifestyle.
proper balance of nutrients and relationships is essential, as in cases of vitamin D with vitamin A. Vitamin A can neutralizebeneficial effects of vitamin D. Moreover, many people are aware that high doses of vitamin A can be toxic to the liver and cause birth defects. But most are not aware that vitamin vitamin DA and compete for their respective functions in the body. Supplement with an excess of vitamin A large effects against cancer, vitamin D can suppress
Most multi preparations containing vitamin A. Vitamin A (or preformed vitamin A) difference in pro-vitamin A, orbeta-carotene. Beta-carotene is not to interfere with vitamin D. It is not beta-carotene are associated with birth defects or liver problems.
The choice of a quality, wide range of branded supplement, is my proposal that offers a beta-carotene (alias for select pro-vitamin A), vitamin A. This is just one of many criteria in choosing a premium Quality fire. When it comes to this section, select a supplement to a daily dose of vitamin D3 at least 2000IU / day, … and observe at least 4,000 IU / day and that your blood tested target of 50-80 ng / ml to achieve.
We should never rely on a vitamin, juice, or magic potion to cure all our problems. But we must not ignore the evidence and promising yet again that science is to explain the benefits that nature provides to help us achieve a level of optimal health.
I am a big supporter of the use of a wide range of high quality vitamins, minerals,antioxidants and essential fatty acids in the proper dosage and balance with a healthy diet and good life. I'm not saying that all answers contained in a vitamin or antioxidant, but many of the responses of optimal health are found in the synergistic effect of the blend and balance of the full extent of the increase we are ready to take in our lives.
